منابع مشابه
Analysis of segmental duplications via duplication distance
MOTIVATION Segmental duplications are common in mammalian genomes, but their evolutionary origins remain mysterious. A major difficulty in analyzing segmental duplications is that many duplications are complex mosaics of fragments of numerous other segmental duplications. RESULTS We introduce a novel measure called duplication distance that describes the minimum number of duplications necessa...
متن کاملShort Segmental Duplication: Parsimony in the Growth of Microbial Genomes
∗ We show that textual analysis of microbial complete genomes reveals telling footprints of their early evolution. If a DNA sequence considered as a text in its four bases is sufficiently random, the distribution of frequencies of words of a fixed length from the text should be Poissonian. We point out that in reality, for words less than nine letters complete microbial genomes universally have...
متن کاملPatterns of segmental duplication in the human genome.
We analyzed the completed human genome for recent segmental duplications (size > or = 1 kb and sequence similarity > or = 90%). We found that approximately 4% of the genome is covered by duplications and that the extent of segmental duplication varies from 1% to 14% among the 24 chromosomes. Intrachromosomal duplication is more frequent than interchromosomal duplication in 15 chromosomes. The d...
متن کاملSegmental duplication of the fetal anterior cerebral artery.
Segmental duplications (also termed 'fenestrations') of the fetal anterior cerebral artery are a relatively rare anomaly. Their occurrence was studied in 200 fetuses at 20-40 wk gestational age. Duplications were found in 21 of the 200 fetuses, i.e. 10.5%. In 2 fetuses, i.e. 1%, the duplications were bilateral. In 1 case, i.e. 0.5%, 2 duplications were found on the left anterior cerebral artery...
متن کاملA segmental genomic duplication generates a functional intron
An intron is an extended genomic feature whose function requires multiple constrained positions-donor and acceptor splice sites, a branch point, a polypyrimidine tract and suitable splicing enhancers-that may be distributed over hundreds or thousands of nucleotides. New introns are therefore unlikely to emerge by incremental accumulation of functional sub-elements. Here we demonstrate that a fu...
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ژورنال
عنوان ژورنال: Bioinformatics
سال: 2015
ISSN: 1367-4803,1460-2059
DOI: 10.1093/bioinformatics/btv481